Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431992 | 0.88 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4EGLAHTT | |
| SCHEMBL12597428 | 0.85 | HTT (0.47) | ALDH1A1L3MBTL1KDM4EHTTLMNA | |
| SCHEMBL31048202 | 0.83 | L3MBTL1 (0.44) | ALDH1A1L3MBTL1KDM4EGLAKMT2A | |
| SCHEMBL5533824 | 0.82 | MTNR1A (0.46) | ALDH1A1L3MBTL1KDM4EGLAKMT2A | |
| SCHEMBL18673195 | 0.76 | HPGD (0.54) | ALDH1A1HTTKMT2AMEN1LMNA | |
| SCHEMBL27099061 | 0.76 | HTT (0.50) | ALDH1A1KDM4EHTTLMNAHPGD | |
| SCHEMBL2068949 | 0.75 | GAA (0.49) | ALDH1A1L3MBTL1KDM4EHTTKMT2A | |
| SCHEMBL4317497 | 0.75 | HTT (0.49) | ALDH1A1L3MBTL1KDM4EHTTLMNA | |
| SCHEMBL13580096 | 0.75 | HTT (0.49) | ALDH1A1L3MBTL1KDM4EHTTLMNA | |
| SCHEMBL4549800 | 0.75 | KDM4E (0.54) | ALDH1A1KDM4EHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2514749-B1 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2015-02-25 | — | — | EP | disclosed |
| US-8754113-B2 | Oxadiazole derivative having endothelial lipase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2014-06-17 | — | — | US | disclosed |
| EP-2514749-A1 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2012-10-24 | — | — | EP | disclosed |
| US-20120253040-A1 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120253040-A1 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY | LIPG, LPL, CEL | ALDH1A1 2861/4885L3MBTL1 266/4885KDM4E 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.