Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | XDH | P47989 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29367989 | 0.89 | MAPT (0.60) | MAPTALDH1A1HPGDPAX8MEN1 | |
| SCHEMBL30140588 | 0.85 | ALDH1A1 (0.82) | MAPTALDH1A1HPGDPAX8TDP1 | |
| SCHEMBL12986562 | 0.85 | MAPT (0.58) | MAPTALDH1A1HPGDPAX8TDP1 | |
| SCHEMBL24687232 | 0.83 | MAPT (1.00) | MAPTALDH1A1HPGDPAX8TDP1 | |
| SCHEMBL12985924 | 0.82 | NOD2 (0.65) | ALDH1A1HPGDTDP1KMT2AABCB1 | |
| SCHEMBL12986941 | 0.82 | ALDH1A1 (0.76) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12986397 | 0.82 | ALDH1A1 (0.60) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29435850 | 0.82 | PLG (0.67) | MAPTALDH1A1HPGDTDP1MEN1 | |
| SCHEMBL16894667 | 0.81 | ABCB1 (0.74) | ALDH1A1MEN1KMT2ADPP4XDH | |
| SCHEMBL16522237 | 0.81 | ALDH1A1 (0.66) | MAPTALDH1A1HPGDPAX8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | claimed |
| CN-106674176-B | 7-substituted-4-aryl coumarin compound and preparation method and application thereof | 西安交通大学 | 2019-12-24 | — | — | CN | disclosed |
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | disclosed |