Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12986397 | 0.90 | ALDH1A1 (0.60) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL29367989 | 0.84 | MAPT (0.60) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL12986381 | 0.82 | MAPT (0.71) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL38660420 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL12986562 | 0.82 | MAPT (0.58) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL3813169 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL13191348 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL30082755 | 0.81 | CYP1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ACYP1A1 | |
| SCHEMBL1764630 | 0.81 | CYP1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ACYP1A1 | |
| SCHEMBL12986680 | 0.81 | KDR (0.65) | ALDH1A1HPGDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | claimed |
| CN-106674176-B | 7-substituted-4-aryl coumarin compound and preparation method and application thereof | 西安交通大学 | 2019-12-24 | — | — | CN | disclosed |
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | disclosed |