Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191308 | 0.90 | MAPT (0.56) | MAPTALDH1A1HPGDPAX8MEN1 | |
| SCHEMBL29367989 | 0.86 | MAPT (0.60) | MAPTEGFRKDRALDH1A1HPGD | |
| SCHEMBL12986381 | 0.85 | MAPT (0.71) | MAPTALDH1A1HPGDPAX8MEN1 | |
| SCHEMBL12986397 | 0.84 | ALDH1A1 (0.60) | MAPTEGFRKDRALDH1A1HPGD | |
| SCHEMBL12986712 | 0.84 | EGFR (0.64) | MAPTEGFRKDRALDH1A1HPGD | |
| SCHEMBL12986941 | 0.82 | ALDH1A1 (0.76) | MAPTKDRALDH1A1HPGDMEN1 | |
| SCHEMBL12986680 | 0.80 | KDR (0.65) | MAPTEGFRKDRALDH1A1HPGD | |
| SCHEMBL5342730 | 0.80 | MAOA (0.56) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12986716 | 0.78 | EGFR (0.62) | MAPTEGFRKDRALDH1A1HPGD | |
| SCHEMBL12985974 | 0.77 | EGFR (0.61) | MAPTEGFRKDRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | claimed |
| WO-2012136910-A1 | DERIVATIVES OF 4-ARYLCOUMARIN AND 4-ARYLQUINOLINE, THERAPEUTIC USES THEREOF AND METHOD FOR SYNTHESISING SAME | UNIVERSITÉ DE MARSEILLE (FR) | 2012-10-11 | — | — | WO | disclosed |