Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.84 |
| ▸ | EBP | Q15125 | 2/20 | 0.84 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.84 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| [11C]Sa4503 SCHEMBL968642 | 0.91 | SIGMAR1 (1.00) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| [11C]Sa4503 SCHEMBL29358558 | 0.91 | SIGMAR1 (1.00) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| [11C]Sa4503 SCHEMBL1299046 | 0.90 | SIGMAR1 (0.97) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| [11C]Sa4503 SCHEMBL29358694 | 0.90 | SIGMAR1 (0.97) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| Hydrochloric Acid SCHEMBL8088187 | 0.90 | SIGMAR1 (0.97) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL8083210 | 0.89 | SIGMAR1 (0.95) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL8086559 | 0.88 | SIGMAR1 (0.92) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| Hydrochloric Acid SCHEMBL8075024 | 0.87 | SIGMAR1 (0.92) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL11939895 | 0.87 | SIGMAR1 (0.78) | SIGMAR1EBPTMEM97EBPL | |
| Hydrochloric Acid SCHEMBL8086545 | 0.86 | SIGMAR1 (0.90) | SIGMAR1EBPTMEM97EBPLABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| EP-1931347-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021545-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRL1 | SIGMAR1 1/4885EBP 1084/4885TMEM97 6/4885 |
| US-20090143395-A1 | Piperazine Derivatives | SIGMAR1, OPRK1, OPRL1 | SIGMAR1 1/4885EBP 1084/4885TMEM97 6/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | SIGMAR1 1/4885EBP 1385/4885TMEM97 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.