Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299376 | 0.80 | CYP3A4 (0.37) | CYP3A4LMNARAB9AHMGCRALDH1A1 | |
| SCHEMBL9152723 | 0.78 | MAOB (0.45) | MAOBHPGDTP53CYP3A4LMNA | |
| SCHEMBL344237 | 0.78 | LMNA (0.33) | CYP3A4LMNARAB9AHTTMAPT | |
| SCHEMBL7956535 | 0.77 | MAOB (0.43) | MAOBHPGDTP53CYP3A4LMNA | |
| SCHEMBL5842993 | 0.77 | TUBB1 (0.33) | CYP3A4MAPTTAAR1ACHEKDM4E | |
| SCHEMBL7959656 | 0.75 | MAOB (0.42) | MAOBHPGDTP53CYP3A4LMNA | |
| SCHEMBL15474681 | 0.75 | MAOB (0.42) | MAOBHPGDTP53CYP3A4LMNA | |
| SCHEMBL2344135 | 0.75 | GAA (0.41) | TP53LMNARAB9AKMT2AALDH1A1 | |
| SCHEMBL2351921 | 0.74 | RAB9A (0.37) | CYP3A4LMNAMEN1RAB9AKMT2A | |
| SCHEMBL1097982 | 0.72 | TUBB1 (0.33) | CYP3A4LMNARAB9AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| EP-1931347-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021545-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRL1 | MAOB 845/4885HPGD 2167/4885TP53 4323/4885 |
| US-20090143395-A1 | Piperazine Derivatives | SIGMAR1, OPRK1, OPRL1 | MAOB 845/4885HPGD 2167/4885TP53 4323/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | MAOB 745/4885HPGD 2033/4885TP53 4274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.