Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13002587 | 0.74 | MAPK1 (0.43) | RAB9ATSHRMAPK1ALDH1A1FGFR1 | |
| SCHEMBL13377453 | 0.73 | WDR5 (0.41) | HTTWDR5ALDH1A1HSP90B1FGFR1 | |
| SCHEMBL12977563 | 0.70 | PTGS2 (0.37) | MAPTALDH1A1LMNA | |
| SCHEMBL12977550 | 0.68 | PTGS2 (0.36) | MAPTALDH1A1HTR2AHTR2CHTR2B | |
| SCHEMBL13233373 | 0.67 | ARG1 (0.42) | WDR5HSP90B1LMNAHPGD | |
| SCHEMBL3981334 | 0.65 | HSP90B1 (0.41) | HTTWDR5MAPTALDH1A1HSP90B1 | |
| SCHEMBL29136623 | 0.61 | LPO (0.52) | MAPTALDH1A1LMNA | |
| SCHEMBL27951252 | 0.61 | HSP90AA1 (0.51) | ALDH1A1HSP90B1LMNA | |
| SCHEMBL3977340 | 0.60 | MEN1 (0.49) | TSHRMAPK1ALDH1A1HSP90B1 | |
| SCHEMBL27556250 | 0.60 | HTT (0.57) | HTTMAPTRAB9ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100303725-A1 | Technetium- and Rhenium-Bis(heteroaryl) Complexes, and Methods of Use Thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2010-12-02 | — | — | US | disclosed |
| US-7824661-B2 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20080025915-A1 | Technetium-And Rhenium-Bis (Heteroaryl) Complexes, And Methods Of Use Thereof | CITIZENS BANK, N.A. | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100303725-A1 | Technetium- and Rhenium-Bis(heteroaryl) Complexes, and Methods of Use Thereof | SLC7A5, RAB35, AADAT | HTT 1873/4885WDR5 883/4885MAPT 3876/4885 |
| US-20080025915-A1 | Technetium-And Rhenium-Bis (Heteroaryl) Complexes, And Methods Of Use Thereof | SLC7A5, RAB35, AADAT | HTT 1873/4885WDR5 883/4885MAPT 3876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.