Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10070523 | 0.78 | ACHE (0.40) | LMNAALDH1A1ELANEMAPTALOX12 | |
| SCHEMBL13818474 | 0.77 | HPGD (0.41) | MAPK1IDO1ALDH1A1HTTL3MBTL1 | |
| SCHEMBL12053511 | 0.76 | IDO1 (0.37) | IDO1 | |
| SCHEMBL10070998 | 0.76 | LMNA (0.32) | LMNASLC6A4SLC6A3 | |
| SCHEMBL8357649 | 0.76 | MAPT (0.38) | MAPK1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL12621700 | 0.76 | ESR2 (0.43) | LMNAALDH1A1RAB9ASIRT1KDM4E | |
| SCHEMBL5704436 | 0.76 | CYP2A6 (0.38) | MAPK1LMNACYP2A6IDO1ALDH1A1 | |
| SCHEMBL11938948 | 0.76 | RAB9A (0.37) | MAPK1ALDH1A1RAB9AKDM4EMAPT | |
| SCHEMBL13356510 | 0.75 | MEN1 (0.48) | LMNASLC6A2SLC6A3L3MBTL1 | |
| SCHEMBL13629548 | 0.74 | CHRNA7 (0.33) | MAPK1CHRNA7LMNAALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| WO-2010127246-A2 | HNF4 MODULATORS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | MAPK1 4775/4885CHRNA7 1170/4885LMNA 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.