Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 15/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | PKM | P14618 | 3/20 | 1.00 |
| ▸ | UBE2I | P63279 | 2/20 | 1.00 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 1.00 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 14/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.74 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15857952 | 0.89 | RAB9A (0.80) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL12319232 | 0.85 | KMT2A (1.00) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL12319226 | 0.78 | KMT2A (0.84) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL12319223 | 0.78 | KMT2A (0.84) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL12319233 | 0.76 | KMT2A (0.62) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7950510 | 0.76 | KMT2A (0.62) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7952321 | 0.75 | KMT2A (0.65) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL18985299 | 0.75 | RAB9A (0.74) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL18985301 | 0.75 | RAB9A (0.74) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6311471 | 0.74 | KMT2A (0.64) | KMT2ARAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9645151-B2 | Targeting phosphofructokinase and its glycosylation form for cancer | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-05-09 | — | — | US | disclosed |
| US-9645151-B2 | Targeting phosphofructokinase and its glycosylation form for cancer | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150369809-A1 | TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2015-12-24 | — | — | US | disclosed |
| US-20150369809-A1 | TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2015-12-24 | — | — | US | disclosed |
| US-8993718-B2 | Methods and compositions for detecting and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993718-B2 | Methods and compositions for detecting and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140187444-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187444-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| US-8524444-B2 | Methods and compositions for detections and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524444-B2 | Methods and compositions for detections and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-03 | — | — | US | disclosed |
| US-20100290987-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-11-18 | — | — | US | disclosed |
| US-20100290987-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150369809-A1 | TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER | PFKFB1, PFKFB2, PGK1 | KMT2A 2647/4885RAB9A 3912/4885NPC1 3164/4885 |
| US-20100290987-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | OGA, IAPP, IDE | KMT2A 4695/4885RAB9A 2300/4885NPC1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.