Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25147600 | 0.75 | NSD3 (0.54) | PTGS2 | |
| SCHEMBL1325079 | 0.74 | FAAH (0.57) | PTGS2PTGS1 | |
| SCHEMBL4211459 | 0.69 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL7677302 | 0.67 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL10300269 | 0.67 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL1302834 | 0.67 | LOXL2 (0.50) | PTGS2PTGS1SYK | |
| SCHEMBL19450642 | 0.67 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL1431534 | 0.67 | IDO1 (0.55) | PTGS2PTGS1 | |
| SCHEMBL4217205 | 0.66 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL2376239 | 0.65 | ENPP2 (0.72) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455528-B2 | Imidazole derivatives useful as inhibitors of FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455528-B2 | Imidazole derivatives useful as inhibitors of FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455528-B2 | Imidazole derivatives useful as inhibitors of FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110269769-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-11-03 | — | — | US | disclosed |
| US-20110269769-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-11-03 | — | — | US | disclosed |
| US-20110269769-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-11-03 | — | — | US | disclosed |
| WO-2009152025-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269769-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | FAAH, FAAH2, HNMT | PTGS2 41/4885PTGS1 14/4885SYK 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.