Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005623 | 0.92 | BRD4 (0.39) | MEN1ALDH1A1MAPK1KMT2ABRD4 | |
| SCHEMBL13060805 | 0.86 | CTSS (0.44) | MEN1KMT2ACTSLCTSSROCK2 | |
| SCHEMBL13060644 | 0.86 | CTSS (0.44) | MEN1KMT2ACTSLCTSSROCK2 | |
| SCHEMBL172990 | 0.84 | CTSL (0.33) | MEN1ALDH1A1MAPK1KMT2ABRD4 | |
| SCHEMBL13061081 | 0.82 | SMYD3 (0.44) | MEN1ALDH1A1KMT2AROCK2ROCK1 | |
| SCHEMBL13060892 | 0.81 | CTSL (0.41) | CTSLCTSSROCK2ROCK1CTSK | |
| SCHEMBL13060890 | 0.81 | CTSL (0.41) | CTSLCTSSROCK2ROCK1CTSK | |
| SCHEMBL13060800 | 0.81 | TAS1R3 (0.41) | ROCK2ROCK1 | |
| SCHEMBL13061114 | 0.81 | TAS1R3 (0.41) | ROCK2ROCK1 | |
| SCHEMBL13061023 | 0.79 | ROCK2 (0.51) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |