Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172828 | 0.87 | CTSL (0.34) | CTSLCTSSUTS2RCTSKROCK2 | |
| SCHEMBL13060641 | 0.84 | MEN1 (0.41) | CTSLCTSSMEN1ALDH1A1MAPK1 | |
| SCHEMBL13005623 | 0.81 | BRD4 (0.39) | CTSLCTSSMEN1ALDH1A1MAPK1 | |
| SCHEMBL172903 | 0.79 | HDAC4 (0.34) | CTSLCTSSUTS2RCTSKROCK2 | |
| SCHEMBL12269509 | 0.74 | TDP1 (0.32) | — | |
| SCHEMBL172786 | 0.74 | TDP1 (0.31) | — | |
| SCHEMBL14186271 | 0.74 | TDP1 (0.31) | — | |
| SCHEMBL10209001 | 0.74 | TDP1 (0.31) | — | |
| SCHEMBL172976 | 0.72 | HDAC4 (0.37) | CTSLCTSSUTS2RCTSK | |
| SCHEMBL13060644 | 0.72 | CTSS (0.44) | CTSLCTSSMEN1KMT2ACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |