Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061025 | 0.93 | CTRB1 (0.52) | MMEMMEL1HDAC4HDAC6CTRB1 | |
| SCHEMBL13005665 | 0.90 | MME (0.51) | MMEMMEL1HDAC4HDAC6HPGDS | |
| SCHEMBL13060829 | 0.90 | UTS2R (0.48) | MMEMMEL1HPGDSCTRB1UTS2R | |
| SCHEMBL13060853 | 0.86 | HDAC4 (0.45) | MMEMMEL1HDAC4UTS2RBCL2 | |
| SCHEMBL13061119 | 0.86 | HDAC4 (0.45) | MMEMMEL1HDAC4UTS2RBCL2 | |
| SCHEMBL13060860 | 0.85 | BCL2 (0.42) | MMEMMEL1HPGDSUTS2RBCL2 | |
| SCHEMBL23116558 | 0.84 | CTRB1 (0.66) | HDAC4HDAC6CTRB1ALDH1A1HDAC1 | |
| SCHEMBL10952300 | 0.84 | CTRB1 (0.66) | HDAC4HDAC6CTRB1ALDH1A1HDAC1 | |
| SCHEMBL13060802 | 0.83 | BCL2 (0.47) | HPGDSALDH1A1UTS2RBCL2KIFC1 | |
| SCHEMBL13060643 | 0.83 | ROCK2 (0.44) | MMEMMEL1HDAC4HDAC6HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |