Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CECR2 | Q9BXF3 | 5/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TAF1 | P21675 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005444 | 0.88 | KCNA5 (0.51) | KCNA5CYP3A4MAP4K1ERN1LMNA | |
| SCHEMBL13060646 | 0.80 | FYN (0.52) | — | |
| SCHEMBL13060800 | 0.77 | TAS1R3 (0.41) | — | |
| SCHEMBL13061114 | 0.77 | TAS1R3 (0.41) | — | |
| SCHEMBL13060892 | 0.75 | CTSL (0.41) | — | |
| SCHEMBL13060890 | 0.75 | CTSL (0.41) | — | |
| SCHEMBL13061023 | 0.75 | ROCK2 (0.51) | — | |
| SCHEMBL13006175 | 0.74 | CYP1A2 (0.47) | CYP3A4LMNAHPGDTSHRHSD17B2 | |
| SCHEMBL13060640 | 0.74 | TAS1R3 (0.40) | — | |
| SCHEMBL17066912 | 0.74 | CYP3A4 (0.53) | KCNA5CYP3A4MAP4K1ERN1CECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |