Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548036 | 0.79 | LMNA (0.61) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL13064020 | 0.79 | ALDH1A1 (0.43) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL13064017 | 0.75 | ADORA3 (0.47) | ALDH1A1CYP3A4AKT1HTTSMN1; SMN2 | |
| SCHEMBL12570475 | 0.71 | PDGFRB (0.43) | LMNAKMT2AHTTSMN1; SMN2POLB | |
| SCHEMBL16578038 | 0.70 | ALDH1A1 (0.58) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL15829874 | 0.69 | FLT3 (0.37) | — | |
| SCHEMBL12593665 | 0.69 | EDNRB (0.45) | ALDH1A1LMNAKMT2AMAPTMEN1 | |
| SCHEMBL10272488 | 0.69 | LMNA (0.47) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL12570771 | 0.67 | NOS3 (0.34) | ALDH1A1LMNAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL2915228 | 0.67 | HSD11B1 (0.53) | ALDH1A1LMNACYP3A4HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138820-A2 | N,N-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-12-02 | — | — | WO | disclosed |