SCHEMBL130675

SCHEMBL130675

COc1ccc(NC(C)=O)cc1-c1c(Br)cnn1C

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.78
HTR2C P28335 20/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5055980 0.87 HTR2A (1.00) HTR2AHTR2C
SCHEMBL5056013 0.86 HTR2A (1.00) HTR2AHTR2C
SCHEMBL19413127 0.86 HTR2A (0.86) HTR2AHTR2C
SCHEMBL3954826 0.86 HTR2A (0.72) HTR2AHTR2C
SCHEMBL14138757 0.86 HTR2A (0.58) HTR2AHTR2C
SCHEMBL171483 0.85 HTR2A (1.00) HTR2AHTR2C
SCHEMBL29574219 0.85 HTR2A (1.00) HTR2AHTR2C
SCHEMBL4209913 0.85 HTR2A (1.00) HTR2AHTR2C
SCHEMBL29573351 0.85 HTR2A (1.00) HTR2AHTR2C
SCHEMBL3949327 0.85 HTR2A (0.70) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200138784-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2020-05-07 US claimed
US-10071075-B2 Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto ARENA PHARMACEUTICALS, INC. (US) 2018-09-11 US claimed
US-20180072680-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2018-03-15 US claimed
US-9353064-B2 Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto ARENA PHARMACEUTICALS, INC. (US) 2016-05-31 US claimed
US-9126946-B2 Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto ARENA PHARMACEUTICALS, INC. (US) 2015-09-08 US claimed
US-20150210648-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2015-07-30 US claimed
US-20110207790-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2011-08-25 US claimed
WO-2010062321-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2010-06-03 WO claimed
US-20220160681-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2022-05-26 US disclosed
US-20220160681-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2022-05-26 US disclosed
US-20200397753-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2020-12-24 US disclosed
US-20200397753-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2020-12-24 US disclosed
US-20200138784-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2020-05-07 US disclosed
US-20200138784-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2020-05-07 US disclosed
US-20080194836-A1 Process for Preparing Substituted Phenylpyrazole Ureas ARENA PHARMACEUTICALS, INC. 2008-08-14 US disclosed
US-20080194836-A1 Process for Preparing Substituted Phenylpyrazole Ureas ARENA PHARMACEUTICALS, INC. 2008-08-14 US disclosed
EP-1879868-A2 PROCESS FOR PREPARING SUBSTITUTED 1-[3-(PYRAZOLYL)PHENYL]-3-PHENYL UREAS Arena Pharmaceuticals, Inc. (US) 2008-01-23 EP disclosed
US-20070293685-A1 reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2007-12-20 US disclosed
US-20070293685-A1 reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2007-12-20 US disclosed
WO-2006081335-A2 PROCESS FOR PREPARING SUBSTITUTED 1- [3- ( PYRAZOLYL) PHENYL] -3-PHENYL UREAS ARENA PHARMACEUTICALS, INC. (US) 2006-08-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210648-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO REN, UACA, IPO4 HTR2A 4233/4885HTR2C 2559/4885
US-10071075-B2 Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto REN, UACA, IPO4 HTR2A 4233/4885HTR2C 2559/4885
US-20200397753-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO HTR2A, HTR5A, HTR1A HTR2A 1/4885HTR2C 5/4885
US-20080194836-A1 Process for Preparing Substituted Phenylpyrazole Ureas HTR5A, HTR2A, HTR2C HTR2A 2/4885HTR2C 3/4885
US-20180072680-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO IPO4, REN, UACA HTR2A 4311/4885HTR2C 2632/4885
US-20220160681-A1 COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO HTR2A, HTR5A, HTR1A HTR2A 1/4885HTR2C 5/4885
US-20110207790-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)UREA AND CRYSTALLINE FORMS RELATED THERETO IPO4, USO1, UACA HTR2A 4375/4885HTR2C 2675/4885
US-20200138784-A1 PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO REN, UACA, IPO4 HTR2A 4233/4885HTR2C 2559/4885
US-20070293685-A1 reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators HTR5A, HTR2C, HTR2A HTR2A 3/4885HTR2C 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.