Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.34 |
| ▸ | CASP6 | P55212 | 2/20 | 0.34 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306707 | 0.90 | P2RX3 (0.40) | ALDH1A1POLBP2RX3CASP3MEN1 | |
| SCHEMBL1305161 | 0.85 | P2RX3 (0.46) | ALDH1A1P2RX3CASP3MEN1KMT2A | |
| SCHEMBL1306160 | 0.80 | KMT2A (0.45) | TRPM4ALDH1A1POLBG6PDP2RX3 | |
| SCHEMBL1306695 | 0.80 | TRPM4 (0.42) | TRPM4ALDH1A1POLBG6PDCASP3 | |
| SCHEMBL1306822 | 0.80 | TSHR (0.38) | TRPM4ALDH1A1POLBG6PDP2RX3 | |
| SCHEMBL1307999 | 0.79 | P2RX3 (0.62) | ALDH1A1P2RX3CASP3MEN1KMT2A | |
| SCHEMBL1305884 | 0.79 | ALDH1A1 (0.41) | ALDH1A1CASP3MEN1KMT2AKDM4E | |
| SCHEMBL1306568 | 0.78 | P2RX3 (0.41) | TRPM4ALDH1A1POLBG6PDP2RX3 | |
| SCHEMBL1306170 | 0.77 | ALDH1A1 (0.48) | ALDH1A1POLBKDM4EHPGDMAPT | |
| SCHEMBL1305454 | 0.77 | P2RX3 (0.42) | TRPM4ALDH1A1POLBG6PDP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |