Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12585557 | 0.88 | DRD2 (0.42) | TAAR1SLC6A3SLC6A2SLC6A4MEN1 | |
| SCHEMBL27817746 | 0.81 | TAAR1 (0.50) | TAAR1SLC6A3SLC6A2SLC6A4MEN1 | |
| SCHEMBL6138472 | 0.79 | MAOA (0.48) | TAAR1KDM4EALDH1A1 | |
| SCHEMBL14018405 | 0.78 | TAAR1 (0.50) | TAAR1SLC6A3SLC6A2SLC6A4IDO1 | |
| SCHEMBL14897365 | 0.76 | S1PR5 (0.42) | MEN1KMT2ALMNASSTR1SSTR4 | |
| Hydrochloric Acid SCHEMBL28672479 | 0.73 | ALDH1A1 (0.47) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL13075727 | 0.72 | MAOA (0.45) | TAAR1SLC6A4KDM4EALDH1A1 | |
| SCHEMBL14285983 | 0.72 | ADRB2 (0.48) | TAAR1SLC6A3SLC6A2SLC6A4KDM4E | |
| SCHEMBL13262052 | 0.72 | LMNA (0.45) | SLC6A3SLC6A2SLC6A4LMNAALDH1A1 | |
| SCHEMBL27353392 | 0.71 | ADRB2 (0.50) | TAAR1SLC6A3SLC6A2SLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| WO-2010131146-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131147-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |