Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071434 | 0.79 | CHRM2 (0.41) | TAAR1PNMTCHRM2SIGMAR1CYP3A4 | |
| SCHEMBL6431428 | 0.79 | SIGMAR1 (0.45) | TAAR1PNMTCHRM2SIGMAR1HSD11B1 | |
| SCHEMBL13075233 | 0.78 | TAAR1 (0.44) | TAAR1SLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL6138472 | 0.77 | MAOA (0.48) | TAAR1SIGMAR1CYP3A4 | |
| SCHEMBL15759296 | 0.77 | CHRM2 (0.53) | TAAR1CHRM2SIGMAR1IDO1AGXT | |
| SCHEMBL25209309 | 0.73 | PNMT (0.48) | TAAR1SLC6A2SLC6A4SLC6A3PNMT | |
| SCHEMBL30174702 | 0.73 | PNMT (0.48) | TAAR1SLC6A2SLC6A4SLC6A3PNMT | |
| SCHEMBL2473095 | 0.73 | MAOA (0.59) | TAAR1SLC6A4SLC6A3PNMTSIGMAR1 | |
| SCHEMBL5222924 | 0.72 | HSD11B1 (0.46) | TAAR1CHRM2SSTR1SSTR4HSD11B1 | |
| Hydrochloric Acid SCHEMBL21879608 | 0.71 | MAOB (0.57) | TAAR1SLC6A4SLC6A3PNMTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |