Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075496 | 0.84 | JAK2 (0.54) | JAK2PTGESHRH1SCN2A | |
| SCHEMBL3797673 | 0.84 | JAK2 (0.42) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3799817 | 0.79 | PDE4A (0.39) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13075509 | 0.74 | PTGES (0.43) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30962796 | 0.70 | ABL1 (0.42) | ABL1SCN9APPARGRORC | |
| SCHEMBL3795873 | 0.69 | PTGES (0.49) | JAK2PTGES | |
| SCHEMBL3798446 | 0.67 | TRPA1 (0.44) | PTGESTRPA1NPY5RSCN9AALDH1A1 | |
| SCHEMBL15401823 | 0.66 | ABL1 (0.60) | JAK2ABL1TRPA1PIK3CD | |
| SCHEMBL3800300 | 0.66 | PTGES (0.43) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL31571903 | 0.66 | P2RX7 (0.40) | MAPK14MPLALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |