Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795873 | 0.85 | PTGES (0.49) | JAK2PTGESDGAT1 | |
| SCHEMBL13075508 | 0.84 | JAK2 (0.41) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3798446 | 0.83 | TRPA1 (0.44) | PTGESDGAT1AURKAKDRERBB2 | |
| SCHEMBL3799817 | 0.80 | PDE4A (0.39) | JAK2PTGESCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25754915 | 0.76 | DGAT1 (0.41) | PTGESDGAT1AURKAKDRERBB2 | |
| SCHEMBL23847031 | 0.71 | TSHR (0.41) | DGAT1AURKAKDRERBB2SMN1; SMN2 | |
| SCHEMBL11245211 | 0.71 | HRH1 (0.56) | NPY5RKDM4EALDH1A1 | |
| SCHEMBL30077144 | 0.71 | AURKA (0.39) | DGAT1RAF1AURKAKDRERBB2 | |
| SCHEMBL15347521 | 0.71 | AURKA (0.39) | DGAT1RAF1AURKAKDRERBB2 | |
| SCHEMBL13075509 | 0.70 | PTGES (0.43) | JAK2PTGESCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |