Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25754915 | 0.90 | DGAT1 (0.41) | DGAT1AURKAKDRERBB2PTGES | |
| SCHEMBL3797673 | 0.83 | JAK2 (0.42) | TRPA1DGAT1AURKAKDRERBB2 | |
| SCHEMBL3795873 | 0.83 | PTGES (0.49) | DGAT1PTGES | |
| SCHEMBL3799944 | 0.80 | TRPA1 (0.40) | TRPA1DGAT1PTPN1PTGESNPY5R | |
| SCHEMBL11251610 | 0.74 | DGAT1 (0.37) | DGAT1AURKAKDRERBB2 | |
| SCHEMBL30568365 | 0.73 | TRPA1 (0.47) | TRPA1PTPN1AXLALDH1A1POLB | |
| SCHEMBL23847031 | 0.72 | TSHR (0.41) | DGAT1AURKAKDRERBB2SMN1; SMN2 | |
| SCHEMBL11247552 | 0.71 | TRPA1 (0.43) | TRPA1PTPN1PTGES | |
| SCHEMBL3584568 | 0.69 | SCN2A (0.58) | DGAT1AURKAKDRERBB2NPY5R | |
| SCHEMBL17868458 | 0.68 | DGAT1 (0.50) | DGAT1SCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |