Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 15/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25754915 | 0.89 | DGAT1 (0.41) | PTGESDGAT1 | |
| SCHEMBL3797673 | 0.85 | JAK2 (0.42) | PTGESJAK2DGAT1 | |
| SCHEMBL3798446 | 0.83 | TRPA1 (0.44) | PTGESDGAT1 | |
| SCHEMBL11251610 | 0.73 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL3797019 | 0.73 | PTGES (0.53) | PTGES | |
| SCHEMBL3800830 | 0.73 | PTGES (0.54) | PTGESJAK2DGAT1 | |
| SCHEMBL11258538 | 0.72 | PTGES (0.50) | PTGESJAK2 | |
| SCHEMBL23847031 | 0.71 | TSHR (0.41) | DGAT1 | |
| SCHEMBL15347521 | 0.71 | AURKA (0.39) | DGAT1 | |
| SCHEMBL11245211 | 0.71 | HRH1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |