Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 5/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799989 | 0.87 | PTGES (0.44) | HSD11B1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL13076233 | 0.80 | RAB9A (0.43) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL13076261 | 0.79 | GRM5 (0.41) | HSD11B1NPC1RAB9APTGESCHRNB2 | |
| SCHEMBL13076379 | 0.79 | GRM5 (0.45) | HSD11B1NPC1RAB9ACHRNB2CHRNA4 | |
| SCHEMBL13076382 | 0.78 | HTT (0.42) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL13076244 | 0.78 | NPC1 (0.43) | HSD11B1NPC1CASP3RAB9ASENP7 | |
| SCHEMBL13076236 | 0.77 | NPC1 (0.45) | HSD11B1NPC1CASP3RAB9ASENP7 | |
| SCHEMBL13076380 | 0.76 | PTGES (0.35) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL13076263 | 0.76 | NPC1 (0.35) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL13076262 | 0.76 | RAB9A (0.45) | NPC1CASP3RAB9ASENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |