SCHEMBL13085014

SCHEMBL13085014

Cc1cc(Cl)cc(C(=O)NCC2CC2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.36
CNR2 P34972 5/20 0.33
CHRM1 P11229 2/20 0.33
CRHR1 P34998 2/20 0.33
MALT1 Q9UDY8 2/20 0.32
MAPK14 Q16539 1/20 0.32
NTRK1 P04629 4/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM3 P20309 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085397 0.95 P2RX7 (0.36) P2RX7CNR2CHRM1CRHR1MALT1
SCHEMBL13084970 0.95 P2RX7 (0.37) P2RX7CNR2CHRM1CRHR1MALT1
SCHEMBL13085250 0.94 P2RX7 (0.37) P2RX7CNR2CHRM1CRHR1NTRK1
SCHEMBL13085152 0.93 P2RX7 (0.35) P2RX7CNR2CHRM1CRHR1NTRK1
SCHEMBL10075295 0.91 ALDH1A1 (0.33) NTRK1
SCHEMBL686481 0.91 CRHR1 (0.36) CRHR1MALT1MAPK14
SCHEMBL10075289 0.90 DHODH (0.33) MALT1
SCHEMBL13085232 0.90 PDE4B (0.34) CNR2CRHR1MALT1MAPK14
SCHEMBL13085026 0.90 P2RX7 (0.35) P2RX7CNR2CHRM1CRHR1MALT1
SCHEMBL13085092 0.90 SLC2A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 P2RX7 288/4885CNR2 2568/4885CHRM1 191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.