Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Cellobiose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.54 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.46 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.46 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.46 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.59 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.59 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | AMY2A | P04746 | 3/20 | 0.53 |
| ▸ | TYR | P14679 | 2/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.49 |
| ▸ | GJA1 | P17302 | 1/20 | 0.48 |
| ▸ | GJB2 | P29033 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | IGF2R | P11717 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maltotriose SCHEMBL2377340 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL16786 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL373436 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL2229473 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Water SCHEMBL466158 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL19582547 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL373437 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL373528 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Cellobiose SCHEMBL7072560 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A | |
| Maltose SCHEMBL230121 | 1.00 | LGALS8 (0.59) | LGALS8LGALS3LGALS4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233969-B2 | DISACCHARIDE DERIVATIVES | PROTHERICS MEDICINES DEV LTD (GB) | 2016-12-14 | — | — | EP | disclosed |
| US-8637659-B2 | Mono-and disaccharide derivatives | PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) | 2014-01-28 | — | — | US | disclosed |
| CN-103127143-A | Inhalation drug composition with budesonide and nitric oxide synthase (NOS) inhibitor | TIANJIN JINYAO GROUP CO LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-103127141-A | Inhalation drug composition with mometasone furoate and nitric oxide synthase (NOS) inhibitor | TIANJIN JINYAO GROUP CO LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-103127144-A | Inhalation drug composition with ciclesonide and nitric oxide synthase (NOS) inhibitor | TIANJIN JINYAO GROUP CO LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-103127133-A | Inhalation drug composition with fluticasone propionate and nitric oxide synthase (NOS) inhibitor | TIANJIN JINYAO GROUP CO LTD | 2013-06-05 | — | — | CN | disclosed |
| US-20120288528-A1 | MONO-AND DISACCHARIDE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 2012-11-15 | — | — | US | disclosed |
| CN-101108250-B | Mono- and disaccharide derivatives | PROTHERICS MEDICINES DEV LTD | 2012-01-11 | — | — | CN | disclosed |
| US-20110305730-A1 | MONO-AND DISACCHARIDE DERIVATIVES | HILGERS LUCAS ALFONSUS T (NL) | 2011-12-15 | — | — | US | disclosed |
| US-8052981-B2 | Mono- and disaccharide derivatives | PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) | 2011-11-08 | — | — | US | disclosed |
| US-20090304723-A1 | Mono-and disaccharide derivatives | BTG INTERNATIONAL LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| EP-1233969-B1 | MONO- AND DISACCHARIDE DERIVATIVES | COVACCINE B V (NL) | 2008-03-05 | — | — | EP | disclosed |
| CN-101108250-A | Mono- and disaccharide derivatives | COVACCINE B V (NL) | 2008-01-23 | — | — | CN | disclosed |
| CN-100345592-C | Mono-and disaccharide derivatives | COVACCINE B V (NL) | 2007-10-31 | — | — | CN | disclosed |
| US-20050256060-A1 | Mono-and disaccharide derivatives | COVACCINE B.V. | 2005-11-17 | — | — | US | disclosed |
| CN-1433423-A | Mono-and disaccharide derivatives | COVACCINE B V (NL) | 2003-07-30 | — | — | CN | disclosed |
| EP-1233969-A2 | MONO- AND DISACCHARIDE DERIVATIVES | Covaccine B.V. (NL) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001040240-A2 | MONO- AND DISACCHARIDE DERIVATIVES | COVACCINE B.V. (NL) | 2001-06-07 | — | — | WO | disclosed |
| EP-1104767-A1 | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups | Stichting Dienst Landbouwkundig Onderzoek (NL) | 2001-06-06 | — | — | EP | disclosed |