Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13110285 | 0.86 | OGA (0.34) | GAAMAPTCAPN9ALDH1A1HTT | |
| SCHEMBL10137516 | 0.80 | MAPT (0.34) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13110289 | 0.80 | PPM1B (0.37) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14348076 | 0.80 | MAPT (0.34) | GAAMAPTCAPN9ALDH1A1MEN1 | |
| SCHEMBL14651109 | 0.76 | ALDH1A1 (0.43) | GAAALDH1A1HTT | |
| SCHEMBL14348069 | 0.76 | ALDH1A1 (0.43) | GAAALDH1A1HTT | |
| SCHEMBL14348073 | 0.76 | ALDH1A1 (0.43) | GAAALDH1A1HTT | |
| SCHEMBL14651075 | 0.76 | ALDH1A1 (0.43) | GAAALDH1A1HTT | |
| SCHEMBL12993310 | 0.75 | CPB1 (0.49) | GAAALDH1A1 | |
| SCHEMBL18202045 | 0.72 | CAPN9 (0.40) | GAAMAPTCAPN9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |