Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311064 | 0.83 | BLM (0.47) | BLMESR1ESR2KMT2ALMNA | |
| SCHEMBL1310507 | 0.83 | ERCC1 (0.36) | BLMKDM4ELMNAALDH1A1CYP3A4 | |
| SCHEMBL1311281 | 0.72 | MEN1 (0.44) | BLMKMT2ALMNAMEN1TSHR | |
| SCHEMBL1336968 | 0.72 | LMNA (0.43) | KMT2ALMNAMEN1EDNRBEDNRA | |
| SCHEMBL6725266 | 0.72 | BLM (0.59) | BLMESR1ESR2KMT2AKDM4E | |
| SCHEMBL6674277 | 0.72 | BLM (0.59) | BLMESR1ESR2KMT2AKDM4E | |
| SCHEMBL1312472 | 0.72 | PTPRB (0.43) | BLMESR1ESR2KMT2ALMNA | |
| SCHEMBL18527956 | 0.71 | MEN1 (0.51) | BLMESR1ESR2KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1334739 | 0.71 | LMNA (0.42) | KMT2ALMNAMEN1EDNRBEDNRA | |
| SCHEMBL12112847 | 0.71 | ITGB3 (0.45) | BLMESR1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275638-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | BIOVITRUM AB (SE) | 2011-11-10 | — | — | US | disclosed |
| EP-2310368-A1 | SMALL MOLECULE LEPTIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2011-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275638-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ADIPOR2, GPR119, ADIPOR1 | BLM 4452/4885ESR1 1456/4885ESR2 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.