Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312915 | 0.83 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1TDP1DRD2RAB9A | |
| SCHEMBL1312421 | 0.76 | DRD2 (0.35) | ALDH1A1KMT2AL3MBTL1DRD2ATM | |
| SCHEMBL1312314 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KMT2AL3MBTL1DRD2RAB9A | |
| SCHEMBL1313252 | 0.73 | L3MBTL1 (0.46) | ALDH1A1KMT2AL3MBTL1DRD2RAB9A | |
| SCHEMBL2856349 | 0.67 | ALDH1A1 (0.54) | ALDH1A1KMT2AL3MBTL1DRD2ATM | |
| SCHEMBL10245202 | 0.65 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1DRD2ATM | |
| SCHEMBL10245151 | 0.65 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1DRD2ATM | |
| SCHEMBL15471248 | 0.65 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1DRD2ATM | |
| SCHEMBL1313787 | 0.64 | ADRA2A (0.37) | ALDH1A1 | |
| SCHEMBL1402224 | 0.63 | L3MBTL1 (0.30) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829039-B2 | Dihydroindolinone derivatives | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110275671-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Indusrty (CN) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275671-A1 | DIHYDROINDOLINONE DERIVATIVES | LCK, CDK5, ABL1 | ALDH1A1 1192/4885KMT2A 2518/4885L3MBTL1 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.