Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 18/20 | 0.58 |
| ▸ | PSMB1 | P20618 | 12/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 11/20 | 0.55 |
| ▸ | PSMB8 | P28062 | 11/20 | 0.55 |
| ▸ | PSMB9 | P28065 | 11/20 | 0.55 |
| ▸ | PSMB6 | P28072 | 11/20 | 0.55 |
| ▸ | PSMB10 | P40306 | 11/20 | 0.55 |
| ▸ | LONP1 | P36776 | 10/20 | 0.55 |
| ▸ | PSMB11 | A5LHX3 | 10/20 | 0.55 |
| ▸ | PSMA7 | O14818 | 10/20 | 0.55 |
| ▸ | PSMA1 | P25786 | 10/20 | 0.55 |
| ▸ | PSMA2 | P25787 | 10/20 | 0.55 |
| ▸ | PSMA3 | P25788 | 10/20 | 0.55 |
| ▸ | PSMA4 | P25789 | 10/20 | 0.55 |
| ▸ | PSMA5 | P28066 | 10/20 | 0.55 |
| ▸ | PSMB4 | P28070 | 10/20 | 0.55 |
| ▸ | PSMB3 | P49720 | 10/20 | 0.55 |
| ▸ | PSMA6 | P60900 | 10/20 | 0.55 |
| ▸ | PSMA8 | Q8TAA3 | 10/20 | 0.55 |
| ▸ | PSMB7 | Q99436 | 10/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464427 | 1.00 | PSMB5 (0.58) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL20093644 | 1.00 | PSMB5 (0.58) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL20365890 | 1.00 | PSMB5 (0.58) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL20365883 | 0.92 | PSMB5 (0.59) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL20093529 | 0.92 | PSMB5 (0.59) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL13130835 | 0.92 | PSMB5 (0.59) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL464494 | 0.92 | PSMB5 (0.59) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL10071801 | 0.82 | PSMB5 (0.70) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL4419103 | 0.82 | PSMB5 (0.70) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL10072156 | 0.82 | PSMB5 (0.70) | PSMB5PSMB1PSMB2PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058874-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-20150005230-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2015-01-01 | — | — | US | disclosed |
| US-20140378414-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC (US) | 2014-12-25 | — | — | US | disclosed |
| US-20140328918-A1 | METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS | CERULEAN PHARMA INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140255374-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | CERULEAN PHARMA INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20130196906-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130059816-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | CERULEAN PHARMA INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20100247669-A1 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | CERULEAN PHARMA INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196906-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | PSMB5 1902/4885PSMB1 2386/4885PSMB2 2374/4885 |
| US-20100247669-A1 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | LPXN, POLI, BRCA1 | PSMB5 1016/4885PSMB1 1551/4885PSMB2 841/4885 |
| US-20140255374-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | PHOSPHO1, SGMS1, SGMS2 | PSMB5 1149/4885PSMB1 1846/4885PSMB2 1429/4885 |
| US-20140328918-A1 | METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS | HLA-DRB1, TSG101, IAPP | PSMB5 650/4885PSMB1 1054/4885PSMB2 856/4885 |
| US-20130059816-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | PHOSPHO1, SGMS1, SGMS2 | PSMB5 1149/4885PSMB1 1846/4885PSMB2 1429/4885 |
| US-20150005230-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | PSMB5 1902/4885PSMB1 2386/4885PSMB2 2374/4885 |
| US-20160058874-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | PSMB5 1902/4885PSMB1 2386/4885PSMB2 2374/4885 |
| US-20140378414-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | PSMG3, COPB1, PSMA6 | PSMB5 18/4885PSMB1 6/4885PSMB2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.