Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRDM9 | Q9NQV7 | 1/20 | 0.40 |
| ▸ | PRDM7 | Q9NQW5 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 2/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13131064 | 0.84 | OGA (0.42) | LRRK2TMEM97OGATSHRCHRM1 | |
| SCHEMBL11947863 | 0.83 | AR (0.41) | HRH4TSHRCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14996508 | 0.82 | PRDM9 (0.42) | PRDM9PRDM7LRRK2TMEM97OGA | |
| SCHEMBL11947818 | 0.81 | CYP2C9 (0.52) | TSHRCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL30306686 | 0.80 | LRRK2 (0.47) | LRRK2TMEM97OGATSHRCYP1A2 | |
| SCHEMBL13168224 | 0.78 | OGA (0.46) | PRDM9PRDM7LRRK2TMEM97OGA | |
| SCHEMBL21186191 | 0.75 | HRH4 (0.50) | PRDM9PRDM7LDHAHRH4CHRM1 | |
| SCHEMBL2629501 | 0.75 | USP2 (0.51) | TSHRCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL11947815 | 0.75 | CYP2C19 (0.53) | TSHRCYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL13131066 | 0.74 | PHGDH (0.43) | TSHRCYP1A2CYP2D6CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | PRDM9 2694/4885PRDM7 4132/4885LRRK2 322/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | PRDM9 2694/4885PRDM7 4132/4885LRRK2 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.