Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRDM9 | Q9NQV7 | 1/20 | 0.42 |
| ▸ | PRDM7 | Q9NQW5 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30306686 | 0.84 | LRRK2 (0.47) | LRRK2TMEM97OGAMEN1KMT2A | |
| SCHEMBL13168224 | 0.82 | OGA (0.46) | PRDM9PRDM7LRRK2TMEM97OGA | |
| SCHEMBL13131094 | 0.82 | PRDM9 (0.40) | PRDM9PRDM7LRRK2HRH4TMEM97 | |
| SCHEMBL14996505 | 0.81 | OGA (0.43) | LRRK2TMEM97OGAMEN1KMT2A | |
| SCHEMBL14996495 | 0.81 | AR (0.43) | HRH4SOS1TSHRCYP2D6CYP2C9 | |
| SCHEMBL14996530 | 0.80 | CYP2C9 (0.56) | MEN1KMT2ATSHRCYP2D6CYP2C9 | |
| SCHEMBL13027974 | 0.79 | HRH4 (0.61) | HRH4MEN1GLAGAAKMT2A | |
| SCHEMBL21186191 | 0.79 | HRH4 (0.50) | PRDM9PRDM7HRH4MEN1GLA | |
| SCHEMBL13131256 | 0.77 | SLC6A2 (0.44) | TLR9TLR8TLR7MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2816087 | 0.76 | SLC6A2 (0.44) | TLR9TLR8TLR7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | PRDM9 2694/4885PRDM7 4132/4885LRRK2 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.