SCHEMBL1313622

SCHEMBL1313622

C=CC(C=C)(Cc1ccccc1C)O[SiH3]

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.36
MAPT P10636 1/20 0.35
ALDH1A1 P00352 1/20 0.33
CDK4 P11802 1/20 0.32
CCND1 P24385 1/20 0.32
CHRM2 P08172 1/20 0.32
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
KMT2A Q03164 3/20 0.31
SSTR4 P31391 1/20 0.31
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.30
MAOB P27338 1/20 0.30
NR3C1 P04150 1/20 0.30
CYP2A13 Q16696 1/20 0.30
PPARG P37231 1/20 0.30
PPARA Q07869 1/20 0.30
TSHR P16473 1/20 0.30
ACHE P22303 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15067885 0.74 ALDH1A1 (0.38) TAAR1ALDH1A1LMNAMAOBPPARG
SCHEMBL1315328 0.74 TAAR1 (0.41) TAAR1ALDH1A1CHRM2PTGS1PTGS2
SCHEMBL1314643 0.70 TAAR1 (0.37) TAAR1ALDH1A1CHRM2PTGS1PTGS2
SCHEMBL28443237 0.69 TAAR1 (0.46) TAAR1MAPTALDH1A1CHRM2PTGS1
SCHEMBL3167835 0.66 RIPK1 (0.48) TAAR1ALDH1A1CHRM2PTGS1PTGS2
SCHEMBL1314470 0.66 TSHR (0.33) TSHRACHE
SCHEMBL710879 0.65 TAAR1 (0.46) TAAR1ALDH1A1CDK4CCND1CHRM2
SCHEMBL1821553 0.65 TAAR1 (0.46) TAAR1ALDH1A1CHRM2PTGS1PTGS2
SCHEMBL87998 0.65 GABRA1 (0.47) TAAR1MAPTALDH1A1CHRM2PTGS1
SCHEMBL896089 0.64 CDK4 (0.42) TAAR1MAPTALDH1A1CDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163950-B2 Processes for the production of tri-organo-monoalkoxysilanes and process for the production of tri-organo-monochlorosilanes SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-04-24 US disclosed
US-20110275849-A1 PROCESSES FOR THE PRODUCTION OF TRI-ORGANO-MONOALKOXYSILANES AND PROCESS FOR THE PRODUCTION OF TRI-ORGANO-MONOCHLOROSILANES BANNOU TADASHI 2011-11-10 US disclosed
US-8008521-B2 Processes for the production of tri-organo-monoalkoxysilanes and process for the production of tri-organo-monochlorosilanes HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2011-08-30 US disclosed
US-20090082585-A1 PROCESSES FOR THE PRODUCTION OF TRI-ORGANO-MONOALKOXYSILANES AND PROCESS FOR THE PRODUCTION OF TRI-ORGANO-MONOCHLOROSILANES BANNOU TADASHI 2009-03-26 US disclosed
US-7459577-B2 Reacting a chlorosilane with grignard reagent SHIN-ETSU CHEMICAL CO., LTD. (JP) 2008-12-02 US disclosed
US-20050070730-A1 Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes SHIN-ETSU CHEMICAL CO., LTD. (JP) 2005-03-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275849-A1 PROCESSES FOR THE PRODUCTION OF TRI-ORGANO-MONOALKOXYSILANES AND PROCESS FOR THE PRODUCTION OF TRI-ORGANO-MONOCHLOROSILANES MLX, HAX1, RPS4X TAAR1 209/4885MAPT 4787/4885ALDH1A1 2163/4885
US-20090082585-A1 PROCESSES FOR THE PRODUCTION OF TRI-ORGANO-MONOALKOXYSILANES AND PROCESS FOR THE PRODUCTION OF TRI-ORGANO-MONOCHLOROSILANES MLX, HAX1, RPS4X TAAR1 209/4885MAPT 4787/4885ALDH1A1 2163/4885
US-20050070730-A1 Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes MLX, HAX1, GRIA3 TAAR1 115/4885MAPT 4809/4885ALDH1A1 2839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.