⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313751 | 0.76 | PARP1 (0.34) | — | |
| SCHEMBL1313248 | 0.72 | NOTUM (0.31) | — | |
| SCHEMBL17104263 | 0.65 | CHRM1 (0.33) | — | |
| SCHEMBL26407645 | 0.55 | CHRNB2 (0.43) | — | |
| SCHEMBL13477930 | 0.55 | SLC6A1 (0.32) | — | |
| SCHEMBL9551510 | 0.53 | BRD4 (0.37) | — | |
| SCHEMBL2292002 | 0.53 | HTR6 (0.42) | — | |
| Hydrochloric Acid SCHEMBL8119686 | 0.52 | BRD4 (0.36) | — | |
| SCHEMBL238942 | 0.52 | HTR6 (0.75) | — | |
| SCHEMBL929913 | 0.52 | LMNA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292613-B1 | DIHYDROINDOLINONE DERIVATIVES | SHANGHAI INST PHARM INDUSTRY (CN) | 2015-09-30 | — | — | EP | disclosed |
| US-8829039-B2 | Dihydroindolinone derivatives | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110275671-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Indusrty (CN) | 2011-11-10 | — | — | US | disclosed |
| EP-2292613-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Industry (CN) | 2011-03-09 | — | — | EP | disclosed |