Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12849095 | 0.87 | ALDH1A1 (0.54) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL12849015 | 0.87 | ALDH1A1 (0.54) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL8443448 | 0.81 | HTR1A (0.48) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL4668006 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL4868499 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL13137654 | 0.79 | CASR (0.43) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL9660672 | 0.78 | SLC6A2 (0.70) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL8207250 | 0.78 | ALDH1A1 (0.56) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL12812166 | 0.78 | TP53 (0.40) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL8751278 | 0.77 | CYP2D6 (0.50) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816408-B2 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090176993-A1 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176993-A1 | Calcium receptor active compounds | CASR, CALCR, CACNA1E | ALDH1A1 3327/4885LMNA 4836/4885HTT 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.