Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19143451 | 0.87 | KDM4E (0.62) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL9905367 | 0.84 | KDM4E (0.59) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL17225693 | 0.83 | KDM4E (0.67) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL3721409 | 0.83 | KDM4E (0.67) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL31434726 | 0.83 | KDM4E (0.67) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL9905485 | 0.82 | KDM4E (0.61) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL1424929 | 0.81 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL9923202 | 0.80 | KDM4E (0.62) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL9923080 | 0.79 | KDM4E (0.61) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL19143309 | 0.79 | KDM4E (0.61) | KDM4ERAB9ANPC1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216798-A2 | KETOLIDE COMPOUNDS | Wockhardt Limited (IN) | 2017-09-13 | — | — | EP | disclosed |
| EP-3216798-A2 | KETOLIDE COMPOUNDS | Wockhardt Limited (IN) | 2017-09-13 | — | — | EP | disclosed |
| EP-2673285-B1 | KETOLIDE COMPOUNDS | WOCKHARDT LTD (IN) | 2017-07-19 | — | — | EP | disclosed |
| CN-105669803-A | KETOLIDE COMPOUNDS | 沃克哈特有限公司 | 2016-06-15 | — | — | CN | disclosed |
| US-20160083412-A1 | KETOLIDE COMPOUNDS | WOCKHARDT LIMITED (IN) | 2016-03-24 | — | — | US | disclosed |
| US-9175031-B2 | Ketolide compounds | WOCKHARDT LIMITED (IN) | 2015-11-03 | — | — | US | disclosed |
| EP-2435460-B1 | KETOLIDE COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | WOCKHARDT LTD (IN) | 2015-01-07 | — | — | EP | disclosed |
| EP-2435460-B1 | KETOLIDE COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | WOCKHARDT LTD (IN) | 2015-01-07 | — | — | EP | disclosed |
| CN-102459296-B | ketolide compounds having antimicrobial activity | WOCKHARDT RESEARCH CENTRE (IN) | 2014-10-29 | — | — | CN | disclosed |
| US-8809538-B2 | Piperidine-containing compounds and use thereof | ARRAY BIOPHARMA INC. (US) | 2014-08-19 | — | — | US | disclosed |
| WO-2012076989-A1 | KETOLIDE COMPOUNDS | WOCKHARDT LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012076989-A1 | KETOLIDE COMPOUNDS | WOCKHARDT LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| US-20120142710-A1 | Ketolide Compounds Having Antimicrobial Activity | WOCKHARDT LIMITED (IN) | 2012-06-07 | — | — | US | disclosed |
| US-20120142710-A1 | Ketolide Compounds Having Antimicrobial Activity | WOCKHARDT LIMITED (IN) | 2012-06-07 | — | — | US | disclosed |
| CN-102459296-A | Ketolide compounds with antimicrobial activity | WOCKHARDT RESEARCH CENTER | 2012-05-16 | — | — | CN | disclosed |
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-11-10 | — | — | US | disclosed |
| WO-2010136971-A1 | KETOLIDE COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | WOCKHARDT RESEARCH CENTRE (IN) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010080864-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142710-A1 | Ketolide Compounds Having Antimicrobial Activity | CYP51A1, AKR1A1, AKR1C1 | KDM4E 128/4885RAB9A 2745/4885NPC1 70/4885 |
| US-20160083412-A1 | KETOLIDE COMPOUNDS | AKR1C3, AKR1D1, AKR1C1 | KDM4E 313/4885RAB9A 891/4885NPC1 452/4885 |
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | NOS1, NOS2, ASS1 | KDM4E 1611/4885RAB9A 2811/4885NPC1 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.