Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | CCL5 | P13501 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13154401 | 0.89 | EPHX2 (0.39) | EPHX2FAAHHTR1AALDH1A1MMP13 | |
| SCHEMBL3316552 | 0.83 | EPHX2 (0.38) | EPHX2FAAHHTR1AALDH1A1MMP13 | |
| SCHEMBL17251906 | 0.82 | NCF1 (0.47) | EPHX2FAAHHTR1AALDH1A1GPR119 | |
| SCHEMBL2603251 | 0.79 | EPHX2 (0.46) | EPHX2FAAHHTR1AMMP13MCOLN3 | |
| SCHEMBL13154410 | 0.79 | KAT5 (0.34) | EPHX2FAAHKAT8 | |
| SCHEMBL10265740 | 0.79 | KDM4E (0.44) | ALDH1A1 | |
| SCHEMBL11990201 | 0.78 | EPHX2 (0.43) | EPHX2FAAHHTR1AALDH1A1MMP13 | |
| SCHEMBL15722324 | 0.78 | EPHX2 (0.43) | EPHX2FAAHHTR1AALDH1A1MMP13 | |
| SCHEMBL13154398 | 0.78 | KAT8 (0.40) | EPHX2FAAHKAT8SMN1; SMN2 | |
| SCHEMBL17404859 | 0.78 | FAAH (0.44) | EPHX2FAAHHTR1AALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975854-B2 | Benzomorphan analogs and use thereof | PURDUE PHARMA L.P. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170073313-A1 | BENZOMORPHAN ANALOGS And Use Thereof | PURDUE PHARMA L.P. | 2017-03-16 | — | — | US | disclosed |
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100234343-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7705158-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073313-A1 | BENZOMORPHAN ANALOGS And Use Thereof | OPRL1, OPRD1, OPRK1 | EPHX2 1757/4885FAAH 144/4885HTR1A 67/4885 |
| US-20100234343-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | EPHX2 1928/4885FAAH 230/4885HTR1A 1665/4885 |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | EPHX2 1928/4885FAAH 230/4885HTR1A 1665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.