Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | RECQL | P46063 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19361289 | 0.86 | ADRB2 (0.55) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL10305082 | 0.84 | TDP1 (0.51) | TDP1KDM4EMAPTRECQLLMNA | |
| Dioxethedrin SCHEMBL249560 | 0.82 | ADRB2 (0.58) | TDP1KDM4EMAPTRECQLLMNA | |
| Dioxethedrin SCHEMBL365011 | 0.81 | KDM4E (0.57) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL11807913 | 0.80 | ADRB1 (0.61) | LMNAHIF1ATSHRNFKB1BLM | |
| SCHEMBL9973165 | 0.76 | MAPT (0.46) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL668000 | 0.76 | KDM4E (0.61) | TDP1KDM4EMAPTRECQLLMNA | |
| Dioxifedrine SCHEMBL250137 | 0.76 | TDP1 (0.61) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL11810223 | 0.76 | ADRB2 (0.59) | LMNAHIF1AALOX15ADRB2ADRB1 | |
| Dioxifedrine SCHEMBL364347 | 0.75 | KDM4E (0.62) | TDP1KDM4EMAPTRECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8491868-B2 | Ligands for imaging cardiac innervation | LANTHEUS MEDICAL IMAGING, INC. (US) | 2013-07-23 | — | — | US | disclosed |
| US-20100221182-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | CITIZENS BANK, N.A. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221182-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | TNNT2, PNMT, TNNC1 | TDP1 3526/4885KDM4E 538/4885MAPT 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.