SCHEMBL1315953

SCHEMBL1315953

O=C(Nc1cc(-c2cncc3ccccc23)ccc1C(=O)O)c1cncc(-c2ccccc2)c1.[NaH]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SERPINE1 P05121 4/20 0.54
▸ MMP9 P14780 2/20 0.49
▸ MMP1 P03956 1/20 0.49
▸ ACLY P53396 3/20 0.49
▸ ALDH1A1 P00352 1/20 0.47
▸ DHODH Q02127 1/20 0.44
▸ ABL1 P00519 1/20 0.44
▸ CSF1R P07333 1/20 0.44
▸ IGF1R P08069 1/20 0.44
▸ PDGFRB P09619 1/20 0.44
▸ KIT P10721 1/20 0.44
▸ FGFR1 P11362 1/20 0.44
▸ FLT1 P17948 1/20 0.44
▸ FLT4 P35916 1/20 0.44
▸ KDR P35968 1/20 0.44
▸ TEK Q02763 1/20 0.44
▸ MCL1 Q07820 1/20 0.43
▸ HDAC1 Q13547 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ GFER P55789 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317959 0.99 SERPINE1 (0.55) SERPINE1MMP9MMP1ACLYALDH1A1
SCHEMBL1315950 0.90 SERPINE1 (0.65) SERPINE1MMP9MMP1ACLYABL1
SCHEMBL1320007 0.86 SERPINE1 (0.49) SERPINE1MMP9MMP1ACLYABL1
SCHEMBL1315751 0.86 ACLY (0.64) SERPINE1ACLYALDH1A1DHODHHDAC1
SCHEMBL1316095 0.84 ACLY (0.52) SERPINE1ACLYALDH1A1DHODHHDAC1
SCHEMBL1317201 0.83 ACLY (0.51) ACLYALDH1A1DHODHMCL1HDAC1
SCHEMBL1317189 0.83 ACLY (0.51) SERPINE1ACLYALDH1A1DHODHHDAC1
SCHEMBL12118197 0.83 ACLY (0.53) SERPINE1ACLYALDH1A1DHODHHDAC1
SCHEMBL1316860 0.83 ACLY (0.58) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1319364 0.82 ACLY (0.52) SERPINE1ACLYALDH1A1DHODHHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 SERPINE1 470/4885MMP9 778/4885MMP1 144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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