SCHEMBL1315969

SCHEMBL1315969

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1ccc(-c2cncnc2)cc1O.[NaH]

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.54
ACMSD Q8TDX5 1/20 0.54
ACLY P53396 8/20 0.53
XDH P47989 2/20 0.49
SLC22A12 Q96S37 2/20 0.49
HDAC1 Q13547 6/20 0.48
HDAC2 Q92769 1/20 0.47
FTO Q9C0B1 1/20 0.46
DHODH Q02127 1/20 0.45
KCNMA1 Q12791 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1319925 0.91 ACLY (0.56) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL1318945 0.89 HDAC1 (0.59) HNF4AACMSDACLYXDHSLC22A12
SCHEMBL1320352 0.89 ACMSD (0.68) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL1315966 0.88 HDAC1 (0.46) HNF4AACMSDACLYXDHSLC22A12
SCHEMBL12117591 0.88 HDAC1 (0.60) HNF4AACMSDACLYXDHSLC22A12
SCHEMBL1317748 0.88 HDAC1 (0.60) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL2272453 0.82 ACLY (0.63) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL1315835 0.82 ACLY (0.57) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL13206516 0.81 ACLY (0.61) HNF4AACMSDACLYHDAC1HDAC2
SCHEMBL1317521 0.80 ACLY (0.68) HNF4AACMSDACLYKCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 HNF4A 1073/4885ACMSD 74/4885ACLY 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.