SCHEMBL1319925

SCHEMBL1319925

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cc(-c2cncnc2)ccc1O

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACLY P53396 5/20 0.56
ACMSD Q8TDX5 3/20 0.54
HNF4A P41235 2/20 0.54
DHFR P00374 1/20 0.54
MCL1 Q07820 1/20 0.54
HDAC1 Q13547 9/20 0.51
HDAC2 Q92769 1/20 0.50
FTO Q9C0B1 1/20 0.46
KDM4E B2RXH2 1/20 0.45
APOBEC3A P31941 1/20 0.45
GFER P55789 1/20 0.45
APOBEC3G Q9HC16 1/20 0.45
DHODH Q02127 1/20 0.45
KCNMA1 Q12791 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1315969 0.91 HNF4A (0.54) ACLYACMSDHNF4AHDAC1HDAC2
SCHEMBL1318525 0.90 ACLY (0.67) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1316020 0.89 HDAC1 (0.62) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1316465 0.88 HDAC1 (0.63) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1316946 0.87 HDAC1 (0.62) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1317299 0.85 HDAC1 (0.46) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL13206537 0.84 ACLY (0.59) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1315416 0.83 ACLY (0.59) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL1316356 0.83 ACLY (0.51) ACLYACMSDHNF4ADHFRMCL1
SCHEMBL2272453 0.82 ACLY (0.63) ACLYACMSDHNF4ADHFRMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885ACMSD 74/4885HNF4A 1073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.