SCHEMBL1316640

SCHEMBL1316640

O=C(O)c1ccc(OCc2ccccc2)c(C(=O)OCc2ccccc2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.56
FOLH1 Q04609 3/20 0.55
HTT P42858 1/20 0.53
KDM4E B2RXH2 1/20 0.53
POLB P06746 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
KMT2A Q03164 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
SLC6A2 P23975 1/20 0.53
SLC6A3 Q01959 1/20 0.53
NR4A2 P43354 2/20 0.53
NR4A1 P22736 1/20 0.53
NR4A3 Q92570 1/20 0.53
LMNA P02545 1/20 0.53
PTGER1 P34995 1/20 0.52
MEN1 O00255 1/20 0.51
RXRA P19793 3/20 0.50
RXRB P28702 2/20 0.50
MRGPRX4 Q96LA9 2/20 0.50
RXRG P48443 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1647432 0.93 TDP1 (0.58) ALDH1A1FOLH1HTTKDM4EPOLB
SCHEMBL9203039 0.90 ALDH1A1 (0.49) ALDH1A1FOLH1HTTKDM4EPOLB
SCHEMBL17747123 0.89 MAOB (0.55) ALDH1A1FOLH1HTTKDM4EPOLB
SCHEMBL1649243 0.88 FOLH1 (0.68) ALDH1A1FOLH1KDM4EPOLBL3MBTL1
SCHEMBL17747097 0.88 SMN1; SMN2 (0.51) ALDH1A1FOLH1HTTKDM4EPOLB
SCHEMBL1646582 0.87 RXRA (0.56) ALDH1A1FOLH1KDM4EPOLBL3MBTL1
SCHEMBL15127666 0.87 ALDH1A1 (0.62) ALDH1A1POLBL3MBTL1KMT2ATDP1
SCHEMBL1316171 0.87 MAPT (0.53) ALDH1A1FOLH1HTTKDM4EKMT2A
SCHEMBL17747100 0.87 SMN1; SMN2 (0.50) ALDH1A1FOLH1HTTKDM4EPOLB
SCHEMBL4941110 0.85 ALDH1A1 (0.68) ALDH1A1KDM4EPOLBL3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
CN-102333757-A N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2012-01-25 CN disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2002044128-A2 SALICYLATE ANALOGS AS INTERLEUKIN-4 ANTAGONISTS SUNESIS PHARMACEUTICALS, INC. (US) 2002-06-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ALDH1A1 813/4885FOLH1 3884/4885HTT 2589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.