Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 3/20 | 0.55 |
| ▸ | RXRB | P28702 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131229 | 0.89 | FOLH1 (0.63) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL7934406 | 0.89 | FOLH1 (0.69) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL1316640 | 0.88 | ALDH1A1 (0.56) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL4295650 | 0.88 | FOLH1 (0.62) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL2634130 | 0.87 | NR4A2 (0.63) | FOLH1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL11536692 | 0.87 | KDM4E (0.62) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL551475 | 0.87 | FOLH1 (0.60) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL383508 | 0.87 | FOLH1 (0.60) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL5485828 | 0.87 | SMPD1 (0.70) | FOLH1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL5485830 | 0.87 | SMPD1 (0.62) | FOLH1NR4A2NR4A1NR4A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
| CN-100519546-C | Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics | UNIVERSTE LOUIS PASTEUR CT NAT (FR) | 2009-07-29 | — | — | CN | disclosed |
| CN-1849312-A | Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics | UNIV PASTEUR (FR) | 2006-10-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184553-A1 | NOVEL COMPOUNDS | LRRK2, PARK7, PINK1 | FOLH1 4250/4885KDM4E 3000/4885ALDH1A1 4183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.