SCHEMBL1316660

SCHEMBL1316660

CC(=O)Oc1ccc(Br)cc1C(=O)Nc1cc(-c2ccccc2)ccc1C(=O)OC(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.50
LMNA P02545 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CFD P00746 1/20 0.43
BACE1 P56817 1/20 0.42
KDM4E B2RXH2 3/20 0.41
RXFP1 Q9HBX9 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
ACLY P53396 3/20 0.41
ALDH1A1 P00352 2/20 0.40
WDR5 P61964 1/20 0.40
HDAC1 Q13547 1/20 0.40
MAPT P10636 3/20 0.40
GAA P10253 1/20 0.40
RECQL P46063 1/20 0.40
ABCG2 Q9UNQ0 2/20 0.39
HDAC2 Q92769 1/20 0.39
TOP1 P11387 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317055 0.90 POLB (0.56) POLBLMNANPSR1CFDKDM4E
SCHEMBL2271130 0.90 HSD17B10 (0.43) LMNACFDBACE1KDM4EHDAC8
SCHEMBL2570784 0.87 POLB (0.56) POLBLMNANPSR1CFDKDM4E
SCHEMBL12117755 0.87 HDAC1 (0.48) POLBLMNANPSR1BACE1KDM4E
SCHEMBL12117742 0.87 ALDH1A1 (0.47) POLBLMNANPSR1BACE1KDM4E
SCHEMBL1316377 0.87 LRRK2 (0.55) POLBLMNANPSR1KDM4EALDH1A1
SCHEMBL1315825 0.84 ACLY (0.47) NPSR1BACE1KDM4ERXFP1HDAC8
SCHEMBL1316797 0.83 LIPG (0.38) POLBLMNANPSR1CFDBACE1
SCHEMBL12117929 0.81 MAPT (0.43) LMNABACE1ACLYALDH1A1HDAC1
SCHEMBL1316241 0.81 KDM4E (0.46) POLBLMNANPSR1CFDBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 POLB 4339/4885LMNA 546/4885NPSR1 4205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.