Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 10/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 8/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14883668 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL18475510 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL29796720 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL12657346 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL12137748 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL9808026 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL15241475 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL15803772 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL20306870 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 | |
| SCHEMBL46197 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147920-B1 | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2016-08-31 | — | — | EP | disclosed |
| US-9415044-B2 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150284333-A1 | Process for the Synthesis of Quaternary Amine Compounds | ALKERMES INC (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150164886-A9 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | MALLINCKRODT INC. (US) | 2015-06-18 | — | — | US | disclosed |
| US-20150164886-A9 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | MALLINCKRODT INC. (US) | 2015-06-18 | — | — | US | disclosed |
| US-9040726-B2 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040726-B2 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2015-05-26 | — | — | US | disclosed |
| US-9029543-B2 | Process for the synthesis of quaternary amine compounds | ALKERMES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| EP-2137189-B1 | PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS | MALLINCKRODT LLC (US) | 2015-05-06 | — | — | EP | disclosed |
| US-20150099773-A1 | PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS | VTESSE LLC | 2015-04-09 | — | — | US | disclosed |
| US-8669366-B2 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120258981-A1 | Process for the Synthesis of Quaternary Amine Compounds | ALKERMES, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-7671204-B2 | N-demethylation of N-methyl morphinans | MALLINCKRODT INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671204-B2 | N-demethylation of N-methyl morphinans | MALLINCKRODT INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20100035910-A1 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | MALLINCKRODT INC. (US) | 2010-02-11 | — | — | US | disclosed |
| WO-2009078990-A1 | N-DEMETHYLATION OF N-METHYL MORPHINANS | MALLINCKRODT INC. (US) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156815-A1 | N-demethylation of N-methyl morphinans | SpecGx LLC | 2009-06-18 | — | — | US | disclosed |
| US-20090156815-A1 | N-demethylation of N-methyl morphinans | SpecGx LLC | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156815-A1 | N-demethylation of N-methyl morphinans | OPRM1, PNMT, OPRD1 | OPRD1 3/4885OPRM1 1/4885OPRK1 6/4885 |
| US-20100035910-A1 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | RAN, RANBP1, NCLN | OPRD1 406/4885OPRM1 60/4885OPRK1 527/4885 |
| US-20120258981-A1 | Process for the Synthesis of Quaternary Amine Compounds | QPCT, QARS1, PNMT | OPRD1 2332/4885OPRM1 1291/4885OPRK1 750/4885 |
| US-20150099773-A1 | PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS | RAN, RANBP1, NCLN | OPRD1 406/4885OPRM1 60/4885OPRK1 527/4885 |
| US-20150164886-A9 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | RAN, RANBP1, NCLN | OPRD1 406/4885OPRM1 60/4885OPRK1 527/4885 |
| US-20150284333-A1 | Process for the Synthesis of Quaternary Amine Compounds | QPCT, QARS1, PNMT | OPRD1 2332/4885OPRM1 1291/4885OPRK1 750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.