Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947527 | 0.85 | NPSR1 (0.56) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL19222909 | 0.85 | NPSR1 (0.56) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL1742555 | 0.83 | ALDH1A1 (0.58) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL2931524 | 0.82 | HSD17B10 (0.57) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL1548607 | 0.81 | ALDH1A1 (0.59) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL1817688 | 0.81 | RAB9A (0.64) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL840217 | 0.81 | ALDH1A1 (0.59) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL7666457 | 0.81 | ALDH1A1 (0.59) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL21760240 | 0.81 | NPSR1 (0.52) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL27428918 | 0.81 | NPSR1 (0.52) | NPSR1ALDH1A1HSD17B10CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249102-A1 | Heterotricyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDINGS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-7749996-B2 | Heterotricyclic metalloprotease inhibitors | Alantos Pharmaceutical Holdings, Inc. (US) | 2010-07-06 | — | — | US | disclosed |
| US-20100087420-A1 | Heterotricyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDINGS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20080207607-A1 | Heterotricyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087420-A1 | Heterotricyclic Metalloprotease Inhibitors | MMP13, MMP3, TIMP3 | NPSR1 1828/4885ALDH1A1 1908/4885HSD17B10 1090/4885 |
| US-20100249102-A1 | Heterotricyclic Metalloprotease Inhibitors | MMP13, MMP3, TIMP3 | NPSR1 1828/4885ALDH1A1 1908/4885HSD17B10 1090/4885 |
| US-20080207607-A1 | Heterotricyclic metalloprotease inhibitors | MMP13, MMP3, TIMP3 | NPSR1 1828/4885ALDH1A1 1908/4885HSD17B10 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.