Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.47 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24992445 | 0.85 | SIRT6 (0.58) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL28860292 | 0.84 | ALDH1A1 (0.63) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 | |
| SCHEMBL12765629 | 0.83 | ADRB1 (0.56) | LMNAMAPT | |
| SCHEMBL24992440 | 0.83 | MEN1 (0.54) | ALDH1A1LMNAHIF1AMAPTNPC1 | |
| SCHEMBL7303075 | 0.82 | ALDH1A1 (0.65) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 | |
| SCHEMBL24992438 | 0.81 | NTSR1 (0.43) | ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL12856135 | 0.81 | ALDH1A1 (0.59) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 | |
| SCHEMBL12625177 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 | |
| SCHEMBL807418 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 | |
| SCHEMBL13682933 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNAHIF1ASLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | ALDH1A1 951/4885LMNA 4351/4885HIF1A 1881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.