Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234581 | 0.87 | RAF1 (0.62) | TBXAS1RETFLT3 | |
| SCHEMBL13200102 | 0.83 | RET (0.57) | RETFLT3 | |
| SCHEMBL13200145 | 0.81 | RAF1 (0.53) | RETFLT3 | |
| SCHEMBL13200082 | 0.80 | EGFR (0.61) | RETFLT3 | |
| SCHEMBL13200059 | 0.80 | RET (0.52) | RETFLT3 | |
| SCHEMBL13200076 | 0.79 | RET (0.49) | RETFLT3 | |
| SCHEMBL13200112 | 0.79 | ALDH1A1 (0.54) | RETFLT3 | |
| SCHEMBL13239632 | 0.78 | RAF1 (0.69) | RETFLT3 | |
| SCHEMBL13199934 | 0.78 | KDM4E (0.71) | RETMAPK10FLT3 | |
| SCHEMBL13200123 | 0.77 | FLT3 (0.53) | RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |