Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.52 |
| ▸ | MMP9 | P14780 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 3/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 4/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2969347 | 0.91 | LMNA (0.53) | MMP2MMP9LMNAKDM4EMEN1 | |
| SCHEMBL13201300 | 0.91 | LMNA (0.53) | MMP2MMP9LMNAKDM4EMEN1 | |
| SCHEMBL8320651 | 0.91 | MMP9 (0.62) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL8325151 | 0.88 | MMP9 (0.62) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL8320621 | 0.84 | POLB (0.60) | MMP2MMP9LMNAMEN1ALDH1A1 | |
| SCHEMBL8319573 | 0.83 | MMP2 (0.44) | MMP2MMP9LMNAALDH1A1KMT2A | |
| SCHEMBL16298354 | 0.83 | MMP2 (0.49) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL13201330 | 0.83 | MMP8 (0.52) | MMP2MMP9MEN1KMT2AMMP12 | |
| SCHEMBL13480199 | 0.83 | MMP2 (0.49) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL8328598 | 0.83 | ALDH1A1 (0.51) | LMNAKDM4EMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |