Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.53 |
| ▸ | MMP9 | P14780 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP15 | P51511 | 1/20 | 0.43 |
| ▸ | MMP16 | P51512 | 1/20 | 0.43 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201328 | 0.97 | CA9 (0.52) | MMP2MMP9ACHECA1CA2 | |
| SCHEMBL2965640 | 0.87 | ACHE (0.55) | MMP2MMP9ACHEEPHX2AKR1C3 | |
| SCHEMBL8328565 | 0.87 | ACHE (0.55) | MMP2MMP9ACHEEPHX2AKR1C3 | |
| SCHEMBL13201315 | 0.86 | MMP2 (0.46) | MMP2MMP9EPHX2MMP12MMP3 | |
| SCHEMBL8324754 | 0.85 | MMP2 (0.48) | MMP2MMP9EPHX2MMP12MMP8 | |
| SCHEMBL13201339 | 0.85 | MMP2 (0.46) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL2963202 | 0.85 | MMP2 (0.48) | MMP2MMP9EPHX2MMP12MMP8 | |
| SCHEMBL8324756 | 0.85 | MMP2 (0.46) | MMP2MMP9CA9MMP12MMP8 | |
| SCHEMBL8319091 | 0.85 | MMP9 (0.46) | MMP2MMP9MMP12MMP8MMP3 | |
| SCHEMBL2961151 | 0.84 | ACHE (0.52) | MMP2MMP9ACHECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |